Issue 12, 2024
From the journal:

Chemical Science

Bioorthogonal chemistry of polyoxometalates – challenges and prospects

Stanislav K. Petrovskii, ORCID logo a   Elena V. Grachova ORCID logo b  and  Kirill Yu. Monakhov ORCID logo *a  

* Corresponding authors

a Leibniz Institute of Surface Engineering (IOM), Permoserstr. 15, Leipzig 04318, Germany
E-mail: kirill.monakhov@iom-leipzig.de

b Institute of Chemistry, St Petersburg University, Universitetskii pr. 26, St. Petersburg 198504, Russia

Abstract

Bioorthogonal chemistry has enabled scientists to carry out controlled chemical processes in high yields in vivo while minimizing hazardous effects. Its extension to the field of polyoxometalates (POMs) could open up new possibilities and new applications in molecular electronics, sensing and catalysis, including inside living cells. However, this comes with many challenges that need to be addressed to effectively implement and exploit bioorthogonal reactions in the chemistry of POMs. In particular, how to protect POMs from the biological environment but make their reactivity selective towards specific bioorthogonal tags (and thereby reduce their toxicity), as well as which bioorthogonal chemistry protocols are suitable for POMs and how reactions can be carried out are questions that we are exploring herein. This perspective conceptualizes and discusses advances in the supramolecular chemistry of POMs, their click chemistry, and POM-based surface engineering to develop innovative bioorthogonal approaches tailored to POMs and to improve POM biological tolerance.

Graphical abstract: Bioorthogonal chemistry of polyoxometalates – challenges and prospects

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Article information

DOI
https://doi.org/10.1039/D3SC06284H
Article type
Perspective
Submitted
28 Nov 2023
Accepted
19 Feb 2024
First published
26 Feb 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2024,15, 4202-4221

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Bioorthogonal chemistry of polyoxometalates – challenges and prospects

S. K. Petrovskii, E. V. Grachova and K. Yu. Monakhov, Chem. Sci., 2024, 15, 4202 DOI: 10.1039/D3SC06284H

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